BindingDB BDBM29278 CHEMBL310671::Garantose::SAC::Saccharimide::Saccharin

BDBM29278 CHEMBL310671::Garantose::SAC::Saccharimide::Saccharin

SMILES O=C1NS(=O)(=O)c2ccccc12

InChI Key InChIKey=CVHZOJJKTDOEJC-UHFFFAOYSA-N

Data 109 KI 3 IC50

PDB links: 8 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 29278

Carbonic anhydrase(Stylophora pistillata)
Centre Scientifique De Monaco

Curated by ChEMBL

BDBM29278(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)

Ki: 40.3nMAssay Description:Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair

UniProtKB/TrEMBL
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Carbonic anhydrase(Stylophora pistillata)
Centre Scientifique De Monaco

Curated by ChEMBL

BDBM29278(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)

Ki: 40.3nMAssay Description:Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assayMore data for this Ligand-Target Pair

UniProtKB/TrEMBL
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Carbonic anhydrase(Anopheles gambiae)
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM29278(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)

Ki: 95nMAssay Description:Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

UniProtKB/TrEMBL
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Carbonic anhydrase(Stylophora pistillata)
Centre Scientifique De Monaco

Curated by ChEMBL

BDBM29278(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)

Ki: 104nMAssay Description:Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair

UniProtKB/TrEMBL
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Carbonic anhydrase(Candida albicans (Yeast))
Universite Degli Studi Di Firenze

BDBM29278(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)

Ki: 736nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

PDB KEGG
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Carbonic anhydrase(Astrosclera willeyana)
Slovak Academy Of Sciences

Curated by ChEMBL

BDBM29278(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)

Ki: 751nMAssay Description:Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration...More data for this Ligand-Target Pair

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Carbonic anhydrase(Sulfurihydrogenibium sp. (strain YO3AOP1))
Universit£

Curated by ChEMBL

BDBM29278(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)

Ki: 876nMAssay Description:Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Carbonic anhydrase(Mycobacterium tuberculosis)
Kochi Medical School

BDBM29278(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)

Ki: 7.15E+3nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

KEGG
UniProtKB/TrEMBL
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Carbonic anhydrase(Saccharomyces cerevisiae)
Balikesir University

Curated by ChEMBL

BDBM29278(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)

Ki: 1.25E+4nMAssay Description:Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Carbonic anhydrase(Cryptococcus neoformans var. grubii (Filobasidiell...)
Universite Degli Studi Di Firenze

BDBM29278(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)

Ki: 3.20E+4nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

PDB MMDB
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Filter my 112 hits

Targets 18▿
- Carbonic anhydrase 2 35
- Carbonic anhydrase 1 29
- Carbonic anhydrase 9 11
- Carbonic anhydrase 10
- Carbonic anhydrase 12 9
- Carbonic anhydrase 7 4
- Carbonic anhydrase 6 2
- Carbonic anhydrase 4 2
- Carbonic anhydrase 14 1
- Protein arginine N-methyltransferase 1 [11-371] 1
- Carbonic anhydrase, alpha family 1
- Beta-carbonic anhydrase 1 1
- Delta carbonic anhydrase 1
- Carbonic anhydrase 5A, mitochondrial 1
- Carbonic anhydrase 3 1
- Cholinesterase 1
- Carbonic anhydrase 5B, mitochondrial 1
- RmtA 1
- ...
Publications 40▿
- J Med Chem 59: 6547-52 (2016) 10
- J Med Chem 57: 3522-31 (2014) 10
- J Med Chem 63: 321-333 (2020) 6
- Bioorg Med Chem Lett 21: 710-4 (2011) 5
- Bioorg Med Chem 25: 3583-3589 (2017) 4
- J Med Chem 61: 1176-1181 (2018) 4
- Bioorg Med Chem Lett 26: 401-5 (2016) 4
- Bioorg Med Chem 22: 1821-31 (2014) 4
- Bioorg Med Chem Lett 18: 836-41 (2008) 4
- Bioorg Med Chem 24: 1095-105 (2016) 4
- Bioorg Med Chem 23: 2303-9 (2015) 3
- Bioorg Med Chem 17: 1158-63 (2009) 3
- Bioorg Med Chem 21: 1522-5 (2013) 3
- Bioorg Med Chem 20: 1403-10 (2012) 3
- Bioorg Med Chem 17: 5054-8 (2009) 3
- Bioorg Med Chem 18: 5498-503 (2010) 2
- Bioorg Med Chem Lett 19: 6649-54 (2009) 2
- Bioorg Med Chem 19: 5023-30 (2011) 2
- Bioorg Med Chem 23: 1728-34 (2015) 2
- J Med Chem 56: 1761-71 (2013) 2
- ACS Med Chem Lett 9: 657-661 (2018) 2
- Bioorg Med Chem 21: 1534-8 (2013) 2
- Bioorg Med Chem Lett 26: 1821-6 (2016) 2
- Bioorg Med Chem 17: 4503-9 (2009) 2
- Bioorg Med Chem 24: 1115-20 (2016) 2
- Bioorg Med Chem Lett 27: 490-495 (2017) 2
- J Med Chem 55: 10742-8 (2012) 2
- Bioorg Med Chem 22: 2939-46 (2014) 2
- Bioorg Med Chem 19: 1847-51 (2011) 2
- Bioorg Med Chem Lett 25: 5485-9 (2015) 2
- Bioorg Med Chem 22: 4537-43 (2014) 2
- J Med Chem 50: 1241-53 (2007) 2
- Bioorg Med Chem 15: 7229-36 (2007) 1
- Bioorg Med Chem Lett 24: 275-9 (2013) 1
- Bioorg Med Chem 20: 2208-13 (2012) 1
- J Med Chem 52: 2226-32 (2009) 1
- Bioorg Med Chem Lett 25: 626-30 (2015) 1
- Bioorg Med Chem Lett 25: 3550-5 (2015) 1
- J Med Chem 52: 3116-20 (2009) 1
- Bioorg Med Chem Lett 26: 1253-9 (2016) 1
Institutions 20▿
- Universit£ 29
- Griffith University 10
- Centre Scientifique De Monaco 8
- Kochi Medical School 7
- Sapienza University Of Rome 6
- University Of Florence 6
- Balikesir University 6
- University Of Tampere And Tampere University Hospital 5
- Latvian Institute Of Organic Synthesis 4
- University of Florida 4
- Ecole Nationale Sup£Rieure De Chimie De Montpellier 4
- University Of Chieti-Pescara 4
- Istituto Di Biochimica Delle Proteine-Cnr 4
- Slovak Academy Of Sciences 3
- Agri Ibrahim Cecen University 3
- University Of Florida 2
- Recep Tayyip Erdogan University 2
- Universite Degli Studi Di Firenze 2
- Istituto Di Bioscienze E Biorisorse 2
- University Of Massachusetts Boston 1
Affinity: 10 to 1.0E+6 nM▿
- Ki 109
- IC50 3
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 1
Catalog Cmpds: 1